Study on the Risk of Metabolic Syndrome Based on UA/Cr Analysis

Nearly 40 percent of US adults meet the criteria for obesity, according to the Centers for Disease Control and Prevention, and one in five Americans has metabolic syndrome, which is linked partly to obesity, according to the Endocrine Society’s Hormone Health Network. Adding to the problem, Newell-Fugate said, is that the typical Western diet may contain 40 percent or more fat.



Metabolic syndrome (MS) is a clinical syndrome in which multiple metabolic abnormalities accumulate in the same individual, including abnormal glucose regulation, abdominal obesity, hypertension, and lipid metabolism disorder. Heredity and environmental factors may also influence the MS pathogenesis. There are many risk factors defining MS, e.g. heredity and environmental factor, but they can't explain all cardiovascular events. Therefore, it is suggested that other risk factors such as inflammatory biomarkers, microalbumin, hyperuricemia should be included in the definition.

Huimin Zhang made a study to explore the epidemiological trend of the relationship between serum uric acid/creatinine ratio (UA/Cr) and MS in middle-aged and old people in Wuhan, Hubei Province, which was published on the journal of Advanced Emergency Medicine. This study used the method of cluster sampling.In 2016, 6570 residents over 45 years old were investigated with a standardized questionnaire, physical examination and biochemical examination. The author found that abnormal UA/Cr ratio could be considered an early biomarker of MS. It provided a new scientific basis for the early detection of MS, the intervention of high-risk population and the reversal of cardiovascular disease.

In all, UA/Cr ratio has important clinical significance for early detection of MS, high-risk population prevention of chronic kidney disease and cardiovascular disease. At the same time, to understand the correlation between UA/Cr and MS is helpful to provide strategies for early prevention of diseases, and to provide ideas for the formulation of health strategies.

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